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Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31 °C. It was first described in 1957. ==Etiology== There are two forms of cold agglutinin disease: 1-primary and 2-secondary. * The primary form is by definition idiopathic, a disease for which no cause is known. * Secondary cold agglutinin disease is a result of an underlying condition. * * In adults, this is typically due to a lymphoproliferative disease such as lymphoma and chronic lymphoid leukemia, or infection. Waldenström's macroglobulinemia may also be positive for cold agglutinins. * * In children, cold agglutinin disease is often secondary to an infection, such as ''Mycoplasma'' pneumonia, mononucleosis, and HIV. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cold agglutinin disease」の詳細全文を読む スポンサード リンク
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